pentobarbital will lessen the level or influence of netupitant/palonosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; stay away from use in clients who are chronically making use of a solid CYP3A4 inducerA awful night time's rest can indicate a foul worki